鱼类促性腺激素抑制激素及其受体的研究进展

促性腺激素抑制激素是2000年由日本学者首次从鹌鹑脑中分离出的一种新型下丘脑神经肽,通过其受体介导参与机体的生长、生殖以及摄食等生理过程。迄今,只在金鱼、斑马鱼、星点东方鲀、罗非鱼以及斜带石斑鱼等几种鱼中鉴定出促性腺激素抑制激素。目前,鱼类促性腺激素抑制激素的生理学功能研究相对较少,且存在争议。鱼类促性腺激素抑制激素及其受体的表达调控以及其他生理学功能仍有待进一步研究。本研究简要总结鱼类促性腺激素抑制激素及其受体的研究进展,并对促性腺激素抑制激素的生理学功能进行概括讨论,旨在加深对鱼类促性腺激素抑制激素的认识和了解,为进一步研究做铺垫。

Progress of research on gonadotropin-inhibitory hormone and its receptors in fish

Gonadotropin-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide which was originally isolated from the quail brain and known for inhibiting the secretion of gonadotropin (GTH) from cultured quail anterior pituitaries. GnIH participates in growth, reproduction, and food intake via the specific seven transmembrane G protein-coupled receptors (GPCRs). To date, GnIH was identified in several teleosts, including goldfish, zebrafish, grass puffer, tilapia and orange-spotted grouper. However, information on the studies of GnIH physiology are limited and contradictory in fish. The regulation of GnIH and its receptor(s) as well as other roles of GnIH awaits further studies in teleosts. This review brifely summarized the progress of research on GnIH and its receptor(s), with special emphasis on the physiological functions of GnIH in fish and we hope that this review will contribute to the futher studies.