氟苯尼考在猪体内混饲给药药动学研究

选取保育舍25日龄仔猪6头,一次性混饲给药66mg/kg氟苯尼考后,进行药物代谢动力学研究,所得数据经PKS药动学分析软件进行处理。结果表明:混饲给药氟苯尼考后,血药浓度与时间关系均符合二室开放模型,其主要药代动力学参数如下:T1/2β为(25.54±6.66)h,CL/F为(3.87×10-3±9.98×10-5)L/(kg.h),Vd/f为(1.4206±0.3349)L/kg,AUC为(230.878±5.955)mg/(h.L),LagTime为(0.1777±0.2514)h,Tmax为(1.3828±0.6463)h,Cmax为(7.4419±0.1207)μg/mL。从以上参数可以看出,保育舍仔猪一次性混饲给药后,氟苯尼考仍表现出吸收迅速、广泛和消除较慢的特点,与直接口灌给药方式比较,混饲给药的最高血药浓度较低,但消除半衰期明显延长,二者的生物利用度相当。

Pharmacokinetics of Florfenicol in Piglet through Oral Administration Mixed with Feed

Six piglets of 25 days old were enclosed in this experiment for pharmacokinetics study on florfenicol after administrated of a dose of 66mg/kg body weight mixed with feed.The data were analyzed with PKS software,the result indicated that:the concentration-time course of florfenicol in body could be described by a two-compartment open mode1,the main pharmacokinetics parameters in blood were as follows:T1/2β(25.54±6.66)h,CL/F(3.87×10-3±9.98×10-5)L/(kg·h),Vd/f(1.4206±0.3349)L/kg,AUC(230.878±5.955)mg/h·L,LagTime(0.1777±0.2514)h,Tmax(1.3828±0.6463)h,Cmax(7.4419±0.1207)μg/mL,which showed that,florfenicol was absorbed quickly,distributed widely,and eliminated slowly.Compared with the simplex oral administration,oral administration mixed with feed would have lower Cmax and longer T1/2βand shared the same bioavailability.