生长抑素受体及其组织表达的研究进展

生长抑素受体是一类通过介导生长抑素,具有多种生物学效应的家族。生长抑素受体家族成员基因都已被克隆,分别位于不同的染色体上。它们的氨基酸序列、分子量、特征性结构也被确定。生长抑素受体在脑和外周器官广泛表达,且有重叠性。表达的特征是具有种属特异性、组织特异性、亚型特异性。此外,生长抑素受体在单核和淋巴细胞上也有表达。肿瘤细胞表达生长抑素受体时也表现出亚型特异性。对生长抑素受体的结构及其组织表达的深入研究可以更好的将之应用于动物的促生长及肿瘤的治疗上。

Progress of somatostatin receptors and its expression in tissue

The family of somatostatin receptors (SSTRs) act on diverse biological effects through mediating somatostatin. The Genes of members have been cloned and located in separate chromosomes, and their amino acid, molecular weight and characteristic structure have been identified. mRNAs for SSTRs is widely expressed in brain and peripheral organs and displays an overlapping but characteristic pattern that is species-specific, tissue-specific, subtype-specific. Moreover, SSTRs is expressed in mononuclear leucocytes, lymphocytes and tumors with the character of subtype-specific. Improvement research on structure and tissue expression of SSTRs is helpful in enhancing animal growth and cancer treatment.