Effect of Food Deprivation on Formalin-Induced Nociceptive Behaviors and Beta-Endorphin and Sex Hormones Concentration in Rats |
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Authors: | Mohammad-Reza Sarookhani Elmira Ghasemi-Dashkhasan Nima Heidari-Oranjaghi Hassan Azhdari-Zarmehri Elaheh Erami Sedighe-Sadat Hosseini |
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Institution: | 1.Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran;;2.Nursing and Midwifery School, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran |
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Abstract: | Background: The present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. Also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. Methods: Food was withdrawn 48 h prior to performing the formalin test, but water continued to be available ad libitum. The formalin was injected into hind plantar paw. Results: There is significant difference between male and female control rats during phase 2B. Following 48-h food deprivation, both male and female rats exhibited enhanced nociceptive behavior in response to formalin. Food deprivation for 12 and 24 h increased and for 48 h decreased beta-endorphin level in male and female rats. Food deprivation for 24 h decreased testosterone level in male, while it had no significant effect on female rats and food deprivation for 48 h decreased testosterone level in both sexes. Food deprivation for 24 h increased estradiol level in female and that for 48 h had no significant effect on male and female rats. Conclusions: The present study demonstrates the existence of food deprivation for 48 h causes enhancement of nociception in the formalin test in male and female rats that has correlation with decrease in plasma beta-endorphin and testosterone levels. Key Words: Rat, Food Deprivation, beta-endorphin, Naloxone |
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