Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera |
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| Authors: | Elena V Girich Anton N Yurchenko Olga F Smetanina Phan Thi Hoai Trinh Ngo Thi Duy Ngoc Mikhail V Pivkin Roman S Popov Evgeny A Pislyagin Ekaterina S Menchinskaya Ekaterina A Chingizova Shamil S Afiyatullov Ekaterina A Yurchenko |
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| Institution: | 1.G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia; (E.V.G.); (O.F.S.); (M.V.P.); (R.S.P.); (E.A.P.); (E.S.M.); (E.A.C.); (S.S.A.); (E.A.Y.);2.Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam; (P.T.H.T.); (N.T.D.N.) |
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| Abstract: | Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity. |
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| Keywords: | Aspergillus terreus Aspergillus flocculosus Penicillium sp marine-derived fungi South China Sea secondary metabolites asterriquinones polyketides neuroprotective activity reactive oxygen species |
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