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Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs |
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| Authors: | Xiaoji Wang Chanshan Lv Junmin Feng Linjun Tang Zhuo Wang Yuqing Liu Yi Meng Tao Ye Zhengshuang Xu |
| Institution: | 1.School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, China; E-Mails: (C.L.); (J.F.); (L.T.);2.Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen 518055, China; E-Mail: ;3.Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; E-Mails: (Z.W.); (Y.L.) |
| Abstract: | Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners. |
| Keywords: | itralamide B cyclodepsipeptide total synthesis structural analogs biological study |