Effects of olaquindox on PLA2 activity and phospholipid metabolism of biomembrane in chicks

AIM: To study the effect of olaquindox on phospholipase A₂ (PLA₂) activity and phospholipid metabolism in biomembrane.METHODS: 150 healthy avin chicks were divided into normal control group and olquindox group.The two groups were fed with same feedstuff without olaquindox.The animals in olquindox group were fed with olquindox at dose of 15mg/kg body weight everyday.The experimental period lasted six weeks.Every week 6 vein blood samples were collected randomly from every group for preparing erythrocyte membrane (ECM) and hepatic mitochondria membrane (MiM).RESULTS: PLA₂ activities of ECM and MiM in olquindox group were significant higher than those in control group from 3 to 6 weeks of experiment (P<0.05，P<0.01).The level of major membrane phospholipids in olquindox group was lower than that in control group (P<0.05,P<0.01).CONCLUSION: Olaquindox affects PLA₂ activity and major phospholipid concentration in ECM and MiM,indicating that olaquindox may induce biomembrane injury.