Exercise intervention improves motor symptoms of Parkinson disease and underlying mechanisms

Parkinson disease (PD) is one of the most common neurodegenerative diseases in the world. Many PD treatment programs are designed to manage motor symptoms by drug or surgical intervention (such as deep brain stimulation Although these regimens improve the symptoms of PD or slow the development of the disease, certain side effects remain unsolved during the treartment, and lack of neuroprotective strategies is still the main problem. Exercise or physical exercise can reduce the risk of PD, and significantly improve the movement symptoms of PD or slow down the development of the disease through different neurobiological mechanisms. This article intends to review the progress in improving the movement symptoms of PD and the possible mechanism of exercise intervention for PD.