Rheological properties and hemoglobin structure of red blood cells in cri-tically ill patients with coronary heart disease |
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| Authors: | HAO Xi-ping YUE Liang-yue LEI Jian-ming LI Zhou-xuan YANG Ji-wang HOU Zeng-tao HUANG Yao-xiong |
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| Institution: | 1. Institute of Biomedical Engineering, Jinan University, Guangzhou 510632, China;2. Luoyang Key Laboratory of Photoelectrical Function Materials, School of Physics and Engineering, Henan University of Science and Technology, Luoyang 471003, China;3. Department of Physics, Guangxi Medical University, Nanning 530021, China |
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| Abstract: | AIM: To study the rheological properties of red blood cells (RBC) and the structure of hemoglobin in critically ill patients with coronary heart disease. METHODS: At pH 7.4, the rheological properties of RBC and the structure of hemoglobin isolated from critically ill patients with coronary heart disease and from healthy people were studied with both static and dynamic imaging techniques and ultraviolet-visible spectroscopy. RESULTS: The rheological properties of RBC from the critically ill patients with coronary heart disease were significantly different from those of healthy people. The bending modulus, which indicates the rigidity of RBC, was greater in the patients than that in healthy people. The absorption spectra of the hemoglobin of critically ill patients with coronary heart disease were almost the same as those of healthy people. CONCLUSION: The morphology and flexibility of RBC in critically ill patients with coronary heart disease are worse than those in healthy people, whereas the structure of hemoglobin in the patients is basically found no difference from that in healthy people. |
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| Keywords: | Coronary disease Erythrocytes Hemoglobin |
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