Temporal and spatioal effects of enriched miRNAs in brain and possible role in neural tube defects |
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Authors: | BAI Bao-ling LI Hui-li CHEN Shu-yuan WANG Xiao-lei ZHANG Qin ZHAO Hui-zhi ZHANG Ting |
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Institution: | Capital Institute of Pediatrics, Beijing 100020, China. |
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Abstract: | MicroRNAs (miRNAs) are known to play an important role in regulating the cell proliferation, differentiation and organogenesis. Abnormal expression of miRNAs is associated with increased risk for various diseases, such as neural tube defects (NTD), which is a severe developmental disease as the result of closing the neural tube incompletely or too early. The present review summarizes some enriched miRNAs in the brain of mammals and their spatial temporal feature, and tries to elaborate the relationship between the aberrant expression of miRNAs and the pathogenesis of NTD. |
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Keywords: | MicroRNA Neural tube defects Mammals |
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