Roles of microRNA in regulation of microangiopathy |
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Authors: | ZHU Zhen-hao WANG Ming |
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Institution: | 1.Second Clinical Medical College,2Kidney Disease Center of Chinese and Western Integrative Medicine,Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. |
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Abstract: | Microangiopathy is characterized by capillary basement membrane thickening and microthrombus formation. The process of microangiopathy involves multiple organs and tissues, and seriously endangers the patients’ health and quality of life during the later stage. Recent evidence shows that microRNAs play an important role in the regulatory mechanism of microangiopathy, including inflammatory response, oxidative stress, abnormalities of glucose and lipid metabolism, abnormal activation of the rennin-angiotensin system and so on. The regulatory mechanism has unique features of microangiopathy in different organs. At present, more and more attention has been paid to the roles of microRNAs in the pathogenesis of microangiopathy. |
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Keywords: | MicroRNA Microangiopathy Regulation |
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