The effect of homocysteine on airway smooth muscle cells and fibroblasts |
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| Authors: | WANG Jian-li ZHAO Ming-wu WANG Xiao-hong LI Shu-lian FU Ming-gui TANG Chao-shu |
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| Institution: | 1. The Third Hospital, Beijing Medical University, Beijing 100083 China;
2. The First Hospital, Beijing Medical University, Beijing 100034 China |
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| Abstract: | AIM: To study the effect of homocysteine (HCY) on proliferation of airway smooth muscle cells and fibroblasts and the effect of HCY on collagen prodution of airway fibroblasts. METHODS: 3H]-TdR incorpora- tion was measured in cultured airway smooth muscle cells. The 3H]-TdR and 3H]-proline incorporation were mea- sured in cultured airway fibroblasts. RESULTS: HCY induced proliferation of airway smooth muscle cells and fibroblasts in a concentration - dependent manner. HCY also induced collagen production of airway fibroblasts in a concentration - dependent manner. The inhibitors of protein kinase C, H7 and polymyxin B, inhibited HCY - induced proliferation of airway smooth muscle cells. CONCLUSIONS: HCY induced proliferation of airway smooth muscle cells and fibroblasts, HCY also induced collagen production of airway fibroblasts. The HCY - induced proliferation of airway smooth muscle cells may be related to the pathway of PKC signal transduction. |
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| Keywords: | Cysteine Muscle smooth Cells Fibroblasts Collagen |
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