Cytoprotective activities of hydroxycinnamic acid amides of serotonin against oxidative stress-induced damage in HepG2 and HaCaT cells |
| |
| Authors: | Jang-Yeol Choi Hyeri Kim Yeo-Jin Choi Atsushi Ishihara Kyoungwhan Back Seong-Gene Lee |
| |
| Institution: | a Department of Biotechnology, Environmental Friendly Agricultural Research Center, Bio-Energy Research Center, Chonnam National University, 300 Yongbong-Dong, Buk-Gu, Gwangju 500-757, Republic of Korea;b Division of Applied Life Sciences, Graduate School of Kyoto University, Kyoto 606-8502, Japan |
| |
| Abstract: | Hydroxycinnamic acid amides of serotonin (HCAAS) caffeoylserotonin (compound 1), p-coumaroylserotonin (compound 2), and feruloylserotonin (compound 3)] are secondary metabolites produced in plants. The aim of this study was to investigate the cytoprotective effects of HCAAS based on intracellular reactive oxygen radical (ROS) generation, lipid peroxidation, protein carbonylation, and phosphorylation of histone H2AX in H2O2 treated-HepG2 and HaCaT cells. We have shown that HCAAS showed various strong antioxidant activities in hydrogen peroxide treated both cell lines, suggesting that these compounds may play as chemotherapeutic agents for preventing or reducing the oxidative stress-induced diseases. |
| |
| Keywords: | Antioxidant Protein carbonylation Hydroxycinnamic acid amide Intracellular ROS Lipid peroxidation Phospho-H2AX |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
