Antibacterial triterpenes from the threatened wood-decay fungus Fomitopsis rosea |
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| Authors: | Milena Popova Boryana Trusheva Melania Gyosheva Iva Tsvetkova Vassya Bankova |
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| Institution: | 1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str. Bl. 9, 1113 Sofia, Bulgaria;2. Institute of Botany, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl. 23, 1113 Sofia, Bulgaria;3. Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria |
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| Abstract: | From a biologically active extract from the fungus Fomitopsis rosea, two new lanostane triterpenes were isolated, 3α-(3′-butylcarboxyacetoxy)oxepanoquercinic acid C 1 and 3α-hydroxy-24-methylene-23-oxolanost-8-en-26-carboxylic acid 2, along with three known triterpenes, 3–5, and the epidioxy sterol derivative 6. The structures of the compounds were elucidated based on their spectral properties. All triterpenes demonstrated antibacterial activity against S. aureus but possessed no antiradical activity against DPPH radicals. |
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| Keywords: | Fomitopsis rosea Wood-rotting fungi Lanostan triterpenes Antibacterial activity |
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