Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum |
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| Institution: | 1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China;2. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, PR China;3. Department of Chemistry, East China Normal University, Shanghai 200062, PR China;4. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, PR China;5. Department of Chemistry, Hoa Lu University, Ninh Binh 40000, Viet Nam;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China;4. Kunming Longjin Pharmaceutical Co., Ltd, Kunming 650503, PR China;1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People''s Republic of China;2. First College of Clinical Medical Science, China Three Gorges University & Yichang Central People''s Hospital, Yichang 443003, People''s Republic of China |
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| Abstract: | One (formosumone A, 1) new and fifteen (2–16) known phenolic compounds were isolated from the leaves of Cratoxylum formosum ssp. pruniflorumm, a substitute for the popular bitter nail tea (“Kuding Tea”) generally used in Southeast Asia. Their structures were determined by extensive spectroscopic analysis and by comparison with literature data. Compound 1 possesses a rare scaffold of a flavanone coupled with a phloroglucinol moiety, representing the first example of such a scaffold from the Clusiaceae family. Among the isolates, toxyloxanthone B (11) and vismione D (12) were found to show remarkable anti-neuroinflammatory effects by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells. Additionally, toxyloxanthone B (11) exhibited significant neuroprotective effect against β-amyloid25–35 (Aβ25–35)-induced cell viability decrease in SH-SY5Y neuroblastoma cells. |
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