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| 呋喃唑酮及其代谢物3-氨基-2-恶唑烷酮在鲤鱼体内的残留规律 | |
| 引用本文： | 黄玉英,彭爱红,黄志勇,蔡鸿瑜,谢增鸿.呋喃唑酮及其代谢物3-氨基-2-恶唑烷酮在鲤鱼体内的残留规律[J].福建农林大学学报(自然科学版),2009,38(2). |
| 作者姓名： | 黄玉英 彭爱红 黄志勇 蔡鸿瑜 谢增鸿 |
| 作者单位： | 1. 福州大学化学化工学院,福建,福州,350002;集美大学生物工程学院,福建,厦门,361021 2. 集美大学生物工程学院,福建,厦门,361021 3. 福州大学化学化工学院,福建,福州,350002 |
| 基金项目： | 福建省高校水产科学技术与食品安全重点实验室基金 |
| 摘 要： | 采用高效液相色谱法(HPLC法)研究呋喃唑酮3-(5-硝基糠醛缩氨基)-2-恶唑烷酮](FZ)在鲤鱼体内的残留规律.结果表明,采用单剂量口灌90 mg.kg-1的FZ,鲤鱼肌肉中FZ含量在停药1 h后达到最高值,为(201.9±7.6)μg.kg-1,在停药后的36 h检测不到FZ,其消除半衰期为4.9 h,平均消除速率为8.5μg.kg-1.h-1.同时还采用高效液相色谱—串联质谱检测方法(HPLC-MS/MS法)进行FZ的主要代谢物3-氨基-2-恶唑烷酮(AOZ)的残留规律研究.结果表明,FZ在鲤鱼体内代谢较快,而AOZ却很难消除.鲤鱼肌肉中AOZ含量在停药6 h后达到最高值,为(227.3±9.6)μg.kg-1,停药24 d后残留量为0.6μg.kg-1,其消除半衰期为91.2 h,平均消除速率为0.4μg.kg-1.h-1. |
| 关 键 词： | 鲤鱼 呋喃唑酮 3-氨基-2-恶唑烷酮 残留规律 |
Pharmacokinetics of furazolidone and its metabolite 3-amina-2-oxazolldinone in Cyprinus carpio |
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| HUANG Yu-ying,PENG Ai-hong,HUANG Zhi-yong,CAI Hong-yu,XIE Zeng-hong.Pharmacokinetics of furazolidone and its metabolite 3-amina-2-oxazolldinone in Cyprinus carpio[J].Journal of Fujian Agricultural and Forestry University,2009,38(2). | |
| Authors: | HUANG Yu-ying PENG Ai-hong HUANG Zhi-yong CAI Hong-yu XIE Zeng-hong |
| Institution: | 1.College of Chemistry and Chemical Engineering;Fuzhou University;Fuzhou;Fujian 350002;China;2.College of Bioengineering;Jimei University;Xiamen;Fujian 361021;China |
| Abstract: | Pharmacokinetic properties of furazolidone 3-(5-nitrofurfurylidenamino)-2-oxazolidinone] and its metabolite 3-amina-2-oxazolldinone in Cyprinus carpio were studied by HPLC.With oral dose of 90 mg·kg-1,peak concentration of furazolidone of(201.9±7.6) μg·kg-1 was reached at 1 h,and the concentration of furazolidone declined with the rate of speed of 8.5 μg·kg-1·h-1 and an elimination half-life of 4.9 h.The residues of furazolidone can not be detected after 36 h,then the residual rule of furazolidone′s main metabolite 3-amina-2-oxazolldinone(AOZ) in C.carpio was studied by HPLC-MS/MS.The maximum level of AOZ in C.carpio was(227.3±9.6) μg·kg-1 after 6 h,the concentration of AOZ was 0.6 μg·kg-1 after 24 d,the elimination half-life of furazolidone was 91.2 h,and rate of speed was 0.4 μg·kg-1·h-1. |
| Keywords: | Cyprinus carpio Linnaeus furazolidone 3-amina-2-oxazolldinone residual rule |
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