干姜附子汤对大鼠心肌缺血-再灌注损伤的保护作用

目的]观察干姜附子汤对大鼠心肌缺血-再灌注引起的氧化应激损伤的保护作用。方法]采用在体结扎大鼠左冠状动脉前降支30 min，再灌注60 min的方法制备心肌缺血再灌注模型。观察干姜附子汤对心电图ST段、心肌梗死百分率、血清丙二醛（MDA）含量、超氧化物歧化酶（S0D）活力等指标的影响。结果]干姜附子汤能有效对抗大鼠心肌缺血再灌注损伤导致的心电图 ST段抬高，缩小心肌梗死百分率、降低血清中 MDA的含量、升高血清SOD的活性。结论]干姜附子汤对大鼠心肌缺血-再灌注引起的氧化应激损伤有保护作用,其机制可能与减少心肌自由基的生成及增强心肌抗氧化能力有关。

Protective Effects of Zingiberis and Acniti Praeparatae Decoction on Myocardial Ischemia-Reperfusion Injury in Rats

This study aimed to investigate the protective effects of zin-giberis and acniti praeparatae decoction on oxidative stress injury induced by my-ocardial ischemia reperfusion in rats. Method] Myocardial ischemia-reperfusion was performed by ligation of the left anterior descending coronary artery for 30 min, fol-lowed by reperfusion for 60 min. The effects of zingiberis and acniti praeparatae decoction on ECG ST segment, myocardial infarction percentage, malondialdehyde （MDA） content in the serum, superoxide dismutase （SOD） activity and other indica-tors were observed. Result] Zingiberis and acniti praeparatae decoction could effec-tively inhibit ECG ST segment elevation caused by myocardial ischemia-reperfusion injuries, reduce the percentage of myocardial infarction, decline the content of MDA in the serum, and increase the activity of SOD. Conclusion] Zingiberis and acniti praeparatae decoction exhibits protective effects on oxidative injuries caused by my-ocardial ischemia-reperfusion injuries in rats, which may be involved in reducing the formation of myocardial free radicals and enhancing antioxidant capacity of my-ocardium.