| 非洲猪瘟病毒VP73蛋白的B细胞表位预测 |
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| 引用本文： | 李倩,姚淑霞.非洲猪瘟病毒VP73蛋白的B细胞表位预测[J].农业科学与技术,2008,9(1):89-93. |
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| 作者姓名： | 李倩 姚淑霞 |
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| 作者单位： | [1]烟台大学化学生物理工学院,山东烟台264005 [2]广西大学生命科学与技术学院,广西南宁530005 |
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| 摘 要： | 非洲猪瘟（African Swine Fever，ASF）是由ASF病毒（AS-FV）引起的猪急性、烈性传染病。ASFV可以编码34种以上的结构蛋白。VP73蛋白作为ASFV主要的抗原性结构蛋白，能够诱导机体产生中和抗体，而且抗原性极为稳定，可作为ASFV的主要诊断试剂。笔者利用生物信息学方法，分析了来自Spain 70株的ASFV VP73蛋白的二级结构，并对该蛋白的B细胞表位进行预测，
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| 关 键 词： | 非洲猪瘟病毒 VP73蛋白 B细胞 表位预测 |
The Prediction of B Cell Epitopes for VP73 Protein of African Fever Virus |
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| LI Qian,YAO Shu-xia.The Prediction of B Cell Epitopes for VP73 Protein of African Fever Virus[J].Agricultural Science ＆ Technology,2008,9(1):89-93. |
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| Authors: | LI Qian YAO Shu-xia |
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| Institution: | LI Qian, YAO Shu-xia (1. Science and Engineering College of Chemistry and Biology, Yantai University, Yantai 264005 ;2. College of Life Science and Technology, Guangxi University, Nanning 530005) |
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| Abstract: | Objective]The B cell epitopes for VP73 protein of African swine fever virus was predicted.Method]Based on the analysis of the amino acid sequence and the flexible regions of VP73 protein,the B cell epitopes for VP73 protein of African swine fever virus were predicted by method of Kyte-Doolitfle,Emini and Jameson-Wolf.Result]The B cell epitopes were located at or adjacent to the N-terminal No.11-18,26-48,73-82,136-150,159-174,181-189,191-210,247-276,279-295,313-323 and 382-392.Conclusion]The multi-parameters analytic method was adopted to predict the B cell epitopes for VP73 protein of African swine fever virus,which laid solid foundation for further characterizing the protein of VP73 and researching epitope vaccine. |
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| Keywords: | African swine fever virus VP73 protein B cell epitope |
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