撒坝猪ESR和FSH-β基因多态性及其与产仔数的关联分析*

 在对762头撒坝猪的ESR和FSH-β基因多态性进行检测的基础上，系统地分析了两个基因座位的基因型及其合并基因型产仔数的影响。结果表明，撒坝猪ESR基因座位的BB基因型和B等位基因的频率最高，FSH-β基因座位的AA基因型和A等位基因的频率最高。在初产胎次的产仔数上，ESR基因以AA型最多（P<0.05或P<0.01），FSH-β基因则以BB型最多（P<0.05或P<0.01），呈现显著的加性遗传效应（P<0.05）；在经产胎次的产仔数上，ESR基因以AB型最高（P<0.05），表现出显著的显性遗传效应（P<0.05或P<0.01），FSH-β基因的3种基因型间则无显著差异（P>0.05）。ESR与FSH-β合并基因型为AABB型的母猪，其初产总仔数及活仔数最多（P<0.05或P<0.01）；AAAB型母猪的经产总仔数与活仔数也明显高于其他基因型（P<0.05或P<0.01）。ESR和FSH-β基因确实与猪产仔数存在一定关联，但ESR基因对产仔数的效应与前人关于ESR BB型为猪产仔数增效基因型的结果明显不同。

Polymorphisms of ESR and FSH-β Genes and Their Association with Litter Sizes of Saba Pigs

Based on the detection of polymorphisms of estrogen (ESR) and follicle stimulating hormone β subunit (FSH-β) genes of 762 Saba pigs, the effects of the two genes on litter sizes were analyzed. The results showed that the frequencies of genotype BB and allele B on ESR gene and genotype AA and allele A on FSH-β gene were the highest in Saba pigs. In the first parity, the total number born (TNB) and the number born alive (NBA) of genotype AA of ESR gene and genotype BB of FSH-β gene were higher than the other two genotypes (P<0.05 or P<0.01), and showed significantly additive effects (P<0.05). In the later parities, the litter sizes of genotype AB of ESR gene were the highest (P<0.05), and showed significant dominance effects (P<0.05 or P<0.01), however,it had no significant differences between different genotypes on FSH-β gene (P>0.05). The TNB and NBA of the combined genotype ESR AA and FSH-β BB (AABB) were higher than those of other genotypes (P<0.05 or P<0.01) in first parity, the TNB and NBA of the combined AAAB were the highest among all genotypes (P<0.05 or P<0.01〖BF〗)in later parities.〖BFQ〗The association of ESR and FSH-β gene with litter sizes were confirmed in the present study, however,the effects of ESR gene on the litter size of Saba pigs were obvious different with the previous results.