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| 阿德福韦与七元瓜环超分子相互作用的研究 | |
| 引用本文： | 胡清华,黄英,傅晓钟,陶朱,薛赛凤,祝黔江.阿德福韦与七元瓜环超分子相互作用的研究[J].贵州大学学报(农业与生物科学版),2011,30(6):511-516. |
| 作者姓名： | 胡清华 黄英 傅晓钟 陶朱 薛赛凤 祝黔江 |
| 作者单位： | 1. 贵州省大环化学及超分子化学重点实验室,贵州贵阳,550025 2. 贵州大学西南药用生物资源教育部工程研究中心,贵州贵阳,550025 3. 贵阳医学院药学院,贵州贵阳,550002 |
| 基金项目： | 国家自然科学基金，贵州省教育厅自然科学基金，贵州省科技厅自然科学基金，贵州省优秀科技教育人才省长专项基金，贵州大学人才引进项目 |
| 摘 要： | 利用紫外吸收光谱法(UV-Vis)、红外光谱法(IR)及差示扫描量热法(DSC)等考察了七元瓜环(Q7])与阿德福韦(PMEA)的相互作用.结果表明:Q7]与PMEA相互作用形成包结比为1∶1的主-客体包合物,包结平衡常数为(2.81±0.04)x104L/mol;在0＜pH＜6范围内均能观察到主客体的相互作用,在... |
| 关 键 词： | 七元瓜环 阿德福韦 紫外吸收光谱法 红外光谱法 固体包合物 |
Interactions of Cucurbit[7 ] uril with Adefovir |
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| HU Qing-hua , HUANG Ying , FU Xiao-zhong , TAO Zhu , XUE Sai-feng , ZHU Qian-jiang.Interactions of Cucurbit[7 ] uril with Adefovir[J].Journal of Mountain Agriculture & Biology,2011,30(6):511-516. | |
| Authors: | HU Qing-hua HUANG Ying FU Xiao-zhong TAO Zhu XUE Sai-feng ZHU Qian-jiang |
| Institution: | 1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guiyang Guizhou 550025, China; 2. The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China, Guizhou University, Guiyang Guizhou 550025, China; 3. School of Pharmacy, Guiyang Medical College, Guiyang Guizhou 550002, China) |
| Abstract: | Interaction of adefovir （PMEA） and cucurbit 7 ] uril（ Q 7 ] ） were investigated by UV-Vis absorption spectroscopy, infrared spectroscopy and differential scanning calorimetry in present work. The results showed that the inclusion ratio of Q 7 ] and PMEA was 1： 1, and the formation constant was （2.81 ± 0.04） ×10^4 L · mol-1. Moreover, the thermodynamic parameters were also showed that the binding process was spontaneous and hydrophobic forces was the main driving forces. In addition, the solid inclusion complex was proved by IR and DSC. |
| Keywords: | Cucurbit [ 7 ] uril Adefovir Ultraviolet absorption spectroscopy Infrared spectroscopy Solid inclusion complex |
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