| 芝芪菌质多糖的分离、纯化及体外抗肿瘤活性初步研究 |
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| 引用本文： | 张雅雯,唐宁,饶玉鹏,张敦林.芝芪菌质多糖的分离、纯化及体外抗肿瘤活性初步研究[J].安徽农学通报,2009,15(13):40-41. |
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| 作者姓名： | 张雅雯 唐宁 饶玉鹏 张敦林 |
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| 作者单位： | 南京晓庄学院生命科学系,江苏南京,211171;南京晓庄学院生命科学系,江苏南京,211171;南京晓庄学院生命科学系,江苏南京,211171;南京晓庄学院生命科学系,江苏南京,211171 |
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| 基金项目： | 南京晓庄学院院级科研项目青年专项(2007NXY28) |
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| 摘 要： | 采用水提、醇沉、离子交换层析等方法分离纯化芝芪菌质多糖,并对各纯化多糖成分进行体外肿瘤细胞增殖的抑制活性测定。用DEAE-32纤维素柱层析分离得到4种纯化的芝芪菌质多糖GAP-1、GAP-2、GAP-3、GAP-4。4种纯化的芝芪菌质多糖均有一定程度的体外抗肿瘤活性,其中适宜浓度的GAP-3的体外肿瘤细胞增殖的抑制活性最好。芝芪菌质纯化多糖对GAP-3K562、SMMC-7721和PC-3细胞增殖抑制作用明显,有一定的抗肿瘤药开发前景。
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| 关 键 词： | 芝芪菌质 纯化多糖 抗肿瘤活性 |
Preparation of Zhiqi Fungal Substance Polysaccharides and Research on their Primary Antitumor Activities |
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| Zhang Yawen et al..Preparation of Zhiqi Fungal Substance Polysaccharides and Research on their Primary Antitumor Activities[J].Auhui Agricultural Science Bulletin,2009,15(13):40-41. |
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| Authors: | Zhang Yawen |
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| Institution: | Department of life science;Nanjing Xiaozhuang college;Nanjing 211171;China |
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| Abstract: | To separate and purify the Zhiqi fungal substance polysaccharides by water extraction, methanol deposition and ion - exchange chromatography, then the effects of the purified polysaccharides on the mice cells＇ vitro antitumor activities was preliminary determined. Four purified polysaccbarides GAP - 1, GAP -2, GAP -3, GAP -4 were obtained. The four purified polysaccharides could promote vitro antitumor activities at certain extent, and GAP -3 showed the best activities. GAP- 3 has relatively high Antitumor activities, and it could be a promising antitumor drug. |
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| Keywords: | Zhiqi Fungal Substance purified polysaccharides antitumor activities |
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