高钼低铜对小鼠睾丸组织脂质过氧化作用的影响

为研究高钼、低铜及两因素协同作用对小鼠睾丸组织脂质过氧化作用的影响,将80只健康雄性昆明系小鼠随机分为4组,分别为对照组(Cu 3 mg/L,Mo 0 mg/L)、高钼组(Cu 3 mg/L,Mo600 mg/L)、低铜组(Cu 0 mg/L,Mo 0 mg/L)、低钼高铜组(Cu 0 mg/L,M0 600 mg/L...

Effects of High Molybdenum and Low Copper on Testis Lipid Per-oxidation of Mice

To investigate the synergistic action of the molybdenum excessive and copper deficiency on testis lipid peroxides of mice,eighty healthy male Kunming mice were randomly divided into 4 groups and animal models were established by adding different doses of molybdenum(600 mg/L) or copper(3 mg/L) into drinking water.On the 90th day,tissues from testis were collected for the determinations of the content of MDA and the activities of SOD and GSH-PX.The results showed that the content of testis organization MDA in the high molybdenum and low copper group was 111%,56.8% and 58.3% higher than that of the control group(P<0.01),high molybdenum group(P<0.01) and low copper group(P<0.01),respectively.The SOD activity in the high molybdenum and low copper group was 45.8%,32.4% and 31.1% lower than that of the control group(P<0.01),high molybdenum group(P<0.01) and low copper group(P<0.01),respectively.The GSH-PX activity of testis organization in the high molybdenum group and the low copper group were 22.1% and 32.8%,significantly lower than that of the control group(P<0.05).The GSH-PX activity in the high molybdenum and low copper group was 45.0% lower than that of the control group(P<0.01).The results indicated that excessive molybdenum(600 mg/L) induce sever damage in the testis.Deficiency copper reduces the oxidation resistance of testis and aggravated the molybdenum toxic action in testis.