| 氟苯尼考联合用药对产ESBLs鸡大肠杆菌抗菌活性的影响 |
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| 引用本文： | 李凤娟,魏永俊,胡功政,苑丽,潘玉善,谷晓霞.氟苯尼考联合用药对产ESBLs鸡大肠杆菌抗菌活性的影响[J].河南农业科学,2009(3). |
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| 作者姓名： | 李凤娟 魏永俊 胡功政 苑丽 潘玉善 谷晓霞 |
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| 作者单位： | 河南农业大学,牧医工程学院,河南,郑州,450002 |
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| 基金项目： | 河南省农业科技成果转化项目，河南省创新型科技人才队伍建设工程项目 |
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| 摘 要： | 为测定氟苯尼考联合用药对临床分离产ESBLs鸡大肠杆菌的抗菌活性的影响,采用纸片扩散法检测ESBLs菌,并用微量液体2倍稀释法测定单独使用氟苯尼考、黏菌素、头孢噻呋、阿米卡星、多西环素、痢菌净、磷霉素,以及氟苯尼考与上述6种药物不同比例联合使用时对鸡大肠杆菌的最小抑菌浓度(MIC).结果发现,临床分离的7株大肠杆菌均产ESBLs,对氟苯尼考、头孢噻呋、痢菌净耐药率高达100%,对阿米卡星、多西环素、磷霉素的耐药率分别为71%、57%、57%.氟苯尼考与黏菌素、阿米卡星、多西环素、痢菌净联合使用时,抗菌活性有所提高,氟苯尼考与多西环素以1:2比例复配时,MIC值下降幅度最大.
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| 关 键 词： | 大肠杆菌 超广谱β-内酰胺酶 氟苯尼考 联合用药 抗菌活性 |
Antibacterial Activity of Florfenicol Combinations against E.coli Producing Extend-spetrum Beta-lactamases in Chickens |
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| LI Feng-juan,WEI Yong-jun,HU Gong-zheng,YUAN Li,PAN Yu-shan,GU Xiao-xia.Antibacterial Activity of Florfenicol Combinations against E.coli Producing Extend-spetrum Beta-lactamases in Chickens[J].Journal of Henan Agricultural Sciences,2009(3). |
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| Authors: | LI Feng-juan WEI Yong-jun HU Gong-zheng YUAN Li PAN Yu-shan GU Xiao-xia |
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| Institution: | College of Animal Husbandry and Veterinary Science;Henan Agricultural University;Zhengzhou 450002;China |
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| Abstract: | To determine the antibacterial activity of florfenicol combinations against E.coli produc-ing extend-spetrum beta-lactamases(ESBLs) in chickens,the minimum inhibitory concentrations(MIC) of florfenicol,colistin,ceftiofur,amikacin,doxycycline,amikacin,fosfomycin and the diffe-rent percentage of florfenicol combinations against the E.coli isolates,which producing ESBLs determined by slip diffusion method,were determined by using liquid double microdilution method.The results showed that all of the seven strai... |
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| Keywords: | E coli ESBLs Florfenicol Combination Antibacterial activity |
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