毒死蜱对大鳞副泥鳅的急性毒性及遗传毒性研究

为了估测毒死蜱的环境毒性,以大鳞副泥鳅为试验动物,设置毒死蜱对其急性毒性和遗传毒性试验,研究毒死蜱对大鳞副泥鳅的半数致死质量浓度(LC50)和红细胞DNA的损伤程度。结果表明:毒死蜱对大鳞副泥鳅24、48、96h的LC50分别为524.76、291.53、193.20μg/L,安全质量浓度(SC)为26.99μg/L;试验各组(毒死蜱质量浓度分别为26.99、45.11、63.23μg/L)的红细胞微核率均高于空白对照组,其最高微核率出现在最高剂量组(63.23μg/L)染毒后的第6天,为4.111‰,微核率与毒死蜱质量浓度和染毒时间呈正相关。毒死蜱具有较强的环境毒性,并表现出明显的时间-剂量效应。

Studies on Acute Toxicity and Genetic Toxicity of Chlorpyrifos to Paramisgurnus dabryanus

The purpose of this study was to evaluate the environmental toxicity of chlorpyrifos.With Paramisgurnus dabryanus as test animal,experiments on the acute toxicity and genetic to-xicity of chlorpyrifos were performed to survey the LC50 and the genetic damage of chlorpyrifos to Paramisgurnus dabryanus.The results showed that the LC50 of chlorpyrifos at 24 h,48 h and 96 h was 524.76 μg/L,291.53 μg/L and 193.20 μg/L,respectively,and its safety concentration was 26.99 μg/L.The micronucleus rates of treatment groups with chlorpyrifos at 26.99 μg/L,45.11 μg/L and 63.23 μg/L were higher than those of the control group.The highest micronucleus rate was 4.111‰,appearing on the 6 th day in the highest concentration test group.The micronucleus rates manifested positive correlation with the test time and test dose of chlorpyrifos.Chlorpyrifos had a strong environmental toxicity and showed a significant time-dose effect.