二氢杨梅素的急性毒理学评价及对酒精性肝损伤的防治效果

二氢杨梅素属黄酮类化合物,具有抗氧化、清除自由基、消炎、止咳、祛痰、镇痛、抑菌、抗高血压、降脂、抗肿瘤、保肝护肝等多种生理活性.通过对二氢杨梅素的急性毒性及对酒精性肝损伤的防治效果进行研究,结果表明:二氢杨梅素毒性很小,且Wistar大鼠口服灌胃的最大耐受量为5.0 g/kg;同时,二氢杨梅素能有效阻止昆明种小鼠体内由酒精导致的肝脏还原型谷胱甘肽耗竭和丙二醛升高,降低甘油三酯含量,减轻肝细胞脂肪变性程度,具有较好的预防和治疗酒精性肝损伤功效.

The Acute Toxicological Evaluation of Dihydromyricetin and Its Control Effect for Alcoholic Hepatic Injury

Dihydromyricetin (DMY) is a kind of flavonoids,which has many prominent biological activities,such as antioxidation,scavenging free radicals,antiphlogosis,relieving cough,apophlegmatic,analgesia,bacteriostasis,antihypertension,descending fat,anticarcinogenic and protecting liver,etc..The acute toxicological of DMY and its control effect on alcoholic hepatic injury were studied in this paper,and the results showed that the toxicity of DMY is very low,and the maximum tolerance dose of Wistar mice was 5.0 g/kg;the DMY could effectively prevent the depletion of glutathione (GSH) and the increase of malondialdehyde (MDA) that induced by alcohol,and DMY also could reduce triglyceride (TG) content and lessen hepatic steatosis in vivo of Kunming mice.Therefore,DMY has a better effect on preventing and treatment of alcoholic hepatic injury.