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| 甘草素在翘嘴鳜细菌性败血症疫苗中的佐剂效果 | |
| 引用本文： | 陈昌福,陈晓辉.甘草素在翘嘴鳜细菌性败血症疫苗中的佐剂效果[J].华中农业大学学报,2000,19(3):256-260. |
| 作者姓名： | 陈昌福 陈晓辉 |
| 作者单位： | 1. 华中农业大学水产学院,武汉430070,中国 2. 高知大学农学部生物资源科学科,高知783-8502,日本 3. 福山大学工学部海洋生物工学科,广岛729-0292,日本 |
| 基金项目： | ThisprojectissupportedbyNaturalScienceFundationofChina !(No .3 9870 5 98) |
| 摘 要： | 从甘草中提取的甘草素（Ｇｌｙ）添加在翘嘴鳜细菌性败血症２种疫苗中的佐剂，即福尔马林知嗜水气单胞菌（ＦＫＣ）菌体脂多糖（ＬＰＳ）中，经添加Ｇｌｙ的疫苗接种后，受免翘嘴鳜头肾中白细胞的吞噬活性和经活菌改毒后的免疫保护率显高于本活加Ｇｌｙ疫苗的免疫组（ｔ测验，Ｐ〈０．０５），表明了Ｇｌｙ具有佐剂效果，但是受兔鱼的凝集抗体效价和补体活性在全部受兔鱼中则没有明显差别（ｔ检测，Ｐ〉０．０５）。 |
| 关 键 词： | 甘草素 疫苗 细菌性败血症 翘嘴鳜 佐剂 |
Adjuvant Effect of Glycyrrhizine in Vaccines against Bacterial Septicemia in Mandarinfish, Siniperca chuatsi Basilewsky |
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| Chen Changfu,Chen Xiaohui,Riichi Kusuda.Adjuvant Effect of Glycyrrhizine in Vaccines against Bacterial Septicemia in Mandarinfish, Siniperca chuatsi Basilewsky[J].Journal of Huazhong Agricultural University,2000,19(3):256-260. | |
| Authors: | Chen Changfu Chen Xiaohui Riichi Kusuda |
| Abstract: | The effect of glycyrrhizine (Gly) from licorice( Glycyrrhiza glabra ) as a adjuvant in vaccines against bacterial septicemia in mandarinfish( Siniperca chuatsi Basilewsky) was studied. Mandarinfish were vaccinated with formalin killed cells (FKC) and lipopolysaccharide (LPS) of Aeromonas hydrophila by injection method with or without Gly. The results showed that the phagocytic activity of leucocytes and relative percent survival (RPS) after challenge with live bacteria in vaccinated groups with Gly were significantly higher than that in groups without Gly, but after vaccination no significant differences were detected in agglutinating antibody titers and complement activity between vaccinated groups with Gly and without Gly. |
| Keywords: | glycyrrhizine vaccine bacterial septicemia Siniperca chuatsi |
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