氯化镉对小鼠精液品质和仔鼠性比的影响

为了探讨不同剂量氯化镉对小鼠雄性生殖及性别比例的影响,取32只雄性昆明小鼠,分成4组,每组每日每千克体重分别皮下注射CdCl20、0.5、1.02、.0 mg,连续5周,然后检测精液品质。结果发现,各试验组小鼠附睾内精子浓度以及精子活力显著下降,精子畸形率显著升高,并呈剂量依赖关系。将以上处理公鼠按1∶2比例与雌鼠交配,计算配种受胎率、妊娠率、窝产仔数和仔鼠性别比例,发现这些指标随处理剂量的增加呈下降趋势,雌/雄性比则呈升高趋势。以上结果表明,镉对小鼠精子生成及精液品质有明显毒性作用,可在一定程度上提高雌性后代的比例。

Effect of CdCl2 on Sperm Quality and Sex Ratio of Mouse Offspring

The effect of CdCl_2 on male mouse reproduction and sex ratio were studied in this paper on the basis ofdosage and processing time.A total of32 male Kunming mice weredivided into 4 groups.Animals in each group were given ahypodermic injection ofCdCl_(2) in dosage of 0,0.5,1,2(mg/kg) every day respectively for five consecutive weeks.Semen quality was then detected.The results showed thatsperm concentration and motility decreased significantly(P<0.05),but sperm abnormalityrate elevatedremarkably(P<0.05)in semen original from epididymisin a dosage dependence relationship,resulting in a low fertility rate,a small litter size and low body weight of the offspring at birth,but a greater female sex ratio in a dosage dependent relationship when the males were used to mate 64 female mice.In conclusion,cadmium chloride is harmful to the sperm leading to a high ratio of female offspring.