妥曲珠利-地克珠利复方溶液对鸡球虫病的疗效和安全性评价

妥曲珠利-地克珠利复方溶液设高、中、低3个剂量组，其中妥曲珠利使用浓度分别为20、10、5 mg/L，同时以百球清、妥曲珠利、地克珠利为对照药物，对鸡人工感染地克珠利耐药的柔嫩艾美耳球虫株进行临床抗球虫疗效试验。为评价妥曲珠利-地克珠利复方溶液对靶动物（鸡）的安全性，对试验鸡只连续30 d在饮水中按推荐剂量的5、10 、20倍给药，分别在第15、30 d 通过对增重、饲料报酬、器官系数、血液生化指标、病理组织学等方面进行观察和检测，与不给药对照组比较，以评价复方溶液的使用安全性。结果表明，复方溶液的低、中、高剂量组及百球清组的抗球虫指数（ACI）分别为112.1、182.5、193.9 和178.8。鸡只对妥曲珠利-地克珠利复方溶液的耐受性好，有较宽的安全使用范围。

Efficacy of Toltrazuril-Diclazuril compounded solution on coccidiosis in chicken and its safety evaluation

In order to study the efficacy of Toltrazuril -Diclazuril compounded solution on coccidiosis in chickens, experimental chickens infected with Eimeria tenella Diclazuril drug-fast strain were divided into different groups, including Toltrazuril-Diclazuril compounded solution of high, medium and low (the concentration of Toltrazuril with 20 mg/L, 10 mg/L and 5 mg/L) three dose groups, the drug control groups of Baycox, Toltrazuril and Diclazuril. And in order to study the safety evaluation of Toltrazuril-Diclazuril compounded solution in chickens, the experimental chickens were divided into 4 groups, including three groups that were fed 5, 10 and 20 times of recommended dose by water for 30 days continuously, and a control group that wasn''t fed drugs, the weight gain, feed remuneration, organ coefficient, blood biochemical indicators and pathological histology of chickens were determined after 15 days and 30 days, respectively. The result showed that ACI of low, medium and high dose groups of compound solution and the group of Baycox were 112.1, 182.5, 193.9 and 178.8, respectively. And the experimental chickens had a good tolerance and a wide range of safe use for the compound solution.