| 甘草主要成分抗H9N2亚型流感病毒作用研究 |
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| 引用本文： | 方炳虎,邱灵才,陈建新,陈良柱,曾振灵,陈杖榴.甘草主要成分抗H9N2亚型流感病毒作用研究[J].广东农业科学,2007(3):66-69. |
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| 作者姓名： | 方炳虎 邱灵才 陈建新 陈良柱 曾振灵 陈杖榴 |
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| 作者单位： | 1. 华南农业大学兽医学院/广东省兽药研制与安全评价重点实验室,广东,广州,510642
2. 广东大华农动物保健品有限公司,广东,新兴,527400 |
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| 摘 要： | 利用H9N2亚型流感病毒鼠肺适应株感染小鼠,以肺指数抑制率、肺组织病毒滴度、死亡保护率和生命延长率为评价指标,研究了甘草酸单铵盐、甘草次酸、甘草黄酮等甘草中3种主要成分和甘草粗提物对感染H9N2亚型流感病毒小鼠的防治效果.结果表明,甘草粗提物及甘草酸单铵盐口服均能显著抑制H9N2亚型流感病毒鼠肺适应株引起的小鼠肺炎实变(P<0.01),甘草粗提物20 mg/kg组能明显延长流感病毒感染小鼠的生存时间.
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| 关 键 词： | 甘草 H9N2亚型流感病毒 小鼠 肺指数抑制率 肺组织病毒滴度 死亡保护率 |
| 文章编号： | 1004-874X(2007)03-0066-04 |
| 修稿时间： | 2007-02-07 |
The anti-influenza H9N2 virus effects of active compounds from Radix Glycyrrhizae |
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| FANG Bing-hu,QIU Ling-cai,CHEN Jian-xin,CHEN Liang-zhu,ZENG Zhen-ling,CHEN Zhang-liu.The anti-influenza H9N2 virus effects of active compounds from Radix Glycyrrhizae[J].Guangdong Agricultural Sciences,2007(3):66-69. |
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| Authors: | FANG Bing-hu QIU Ling-cai CHEN Jian-xin CHEN Liang-zhu ZENG Zhen-ling CHEN Zhang-liu |
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| Institution: | 1. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation/College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China ; 2. Guangdong Dahuanong Animal Health Product Corporation Limited, Xinxing 527439, China |
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| Abstract: | The mouse model with viral pneumonia by influenza H9N2 virus was adopted.The anti-influenza virus effects of Radix Glycyrrhizae extract,glycyrrhetate,glycyrrhetic acid and licoflavone were investigated basing on the lung index,the viral titer in mouse lung and death-protection rate.The results showed that the Radix Glycyrrhizae extract and glycyrrhetate remarkably inhibited the lung consolidation of mice pneumonia caused by the infection of influenza H9N2 virus.Radix Glycyrrhizae extract at the concentration of 20 mg/kg prolonged the survival time of mice infected with influenza virus. |
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| Keywords: | active compounds from Radix Glycyrrhizae H9N2 influenza virus mice lung index the viral titer in mouse lung death-protection rate |
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