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持续、低剂量金霉素对肉仔鸡免疫机能的抑制作用研究
引用本文:佟建明,张日俊,等.持续、低剂量金霉素对肉仔鸡免疫机能的抑制作用研究[J].中国农业科学,2001,34(2):200-204.
作者姓名:佟建明  张日俊
作者单位:[1]中国农业科学院畜牧研究所,北京100094 [2]中国农业大学动物科技学院
基金项目:国家科技攻关项目(99-009-02-01),饲料专用抗生素及配套生态技术研究与开发
摘    要:270只Abore Acre商品代肉用公鸡随机分成3组,金霉素在饲料中添加水平分别为0、50只和150mg/kg,研究饲用金霉素对肉仔鸡法氏囊、脾脏和胸腺等免疫器官发育、以及免疫反应的影响。结果表明50mg/kg的金霉素对肉仔鸡脾脏和21日龄的胸腺无明显抑制作用,对T、B淋巴细胞转化率也无明显抑制作用(P<0.05),而且显著促进法氏囊的萎缩(P<0.05)。金霉素对T淋巴细胞转化率有明显的直接抑制作用;50mg/kg和150mg/kg的金素对BAS特异性抗体的产生均有显著的抑制作用(P<0.01)。研究结果表明,持续、低剂量和金霉素对肉 鸡免疫器官发育和免疫应答具有显著的抑制作用,抑制作用随剂量增加而加强,150mg/kg的金霉素对肉仔鸡具有显著促生长作用。

关 键 词:免疫抑制  金霉素  肉仔鸡
文章编号:0578-1752(2001)02-0200-05
修稿时间:2000年2月15日

Immunosuppressant Effect of Long Term and Subtherapeutic Chlortetracycline in Broiler
TONG Jian-ming,ZHANG Ri-jun,SA Ren-na,PAN Shu-yuan,HUANG Yan.Immunosuppressant Effect of Long Term and Subtherapeutic Chlortetracycline in Broiler[J].Scientia Agricultura Sinica,2001,34(2):200-204.
Authors:TONG Jian-ming  ZHANG Ri-jun  SA Ren-na  PAN Shu-yuan  HUANG Yan
Abstract:Experiments were conducted with 270 Abore Acre male broilers to study the influence of dietary chlortetracycline(CTC) on the bursal, thymus and spleen weight index and T,B cell proliferation and antibody responses of broilers. Results show that 50mg/kg CTC had no significant inhibitory effect on thymus and spleen weight index, and T,B cell proliferation of broilers at 21 day old. 150mg/kg CTC had significant inhibitory effect on bursal , thymus and spleen, and T,B cell proliferation(P<0. 05). Dietary CTC had a direct inhibitory effect on lymphocyte proliferation in vitro . 50mg/kg and 150mg/kg CTC have significant inhibitory effect on the antibody responses to BSA(P<0. 01). Results demonstrated that sub-therapeutic and long term CTC had significant inhibitory effects on immune organs and antibody response. The immunosuppressant effect became higher when the level of CTC increased. 150mg/kg CTC increased the growth rate of broilers significantly.
Keywords:Immunosuppression  Chlortetracycline  Broiler
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