骨形态发生蛋白2（BMP2）基因在内蒙古绒山羊不同时期皮肤毛囊中的表达

 【目的】研究内蒙古绒山羊毛囊发育兴盛期和休止期BMP2基因在皮肤毛囊中的表达情况。【方法】功能分类基因芯片以及原位杂交技术。【结果】原位杂交结果表明，该基因在休止期毛囊毛干周围高表达，在兴盛期不表达;基因芯片结果显示，同兴盛期相比，休止期BMP2基因在皮肤中表达上调24.65倍。【结论】BMP2基因抑制内蒙古绒山羊皮肤毛囊发育，与维持皮肤毛囊处于休止期有关；该基因主要在皮肤毛囊的毛干周围发挥作用，从而达到维持皮肤毛囊发育处于休止期的作用。

Expression of BMP2 in the Skin and Hair Follicle from Different Stage in Inner Mongolia Cashmere Goat

To explore the expression of BMP2 in the skin and hair follicle in Inner Mongolia cashmere goat from different stage of hair follicle development by GEArray S Series Stem Cell Array（Supper Array）and in situ hybridization. Try to explain the mode of action of this genes during the development and cycling of hair follicle. The result show the expression of BMP2 was up-regulated in the skin in telogen. whereas it expressed weakly in anagen. The result also indicates that BMP2 mRNA express highly around the hair shaft during the telogen.