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O/W型药用微乳的制备及评价
引用本文:刘根新,张继瑜,吴培星,李剑勇,刘英,周绪正,魏小娟,牛建荣,李冰.O/W型药用微乳的制备及评价[J].中国农业科学,2009,42(9):3328-3333.
作者姓名:刘根新  张继瑜  吴培星  李剑勇  刘英  周绪正  魏小娟  牛建荣  李冰
作者单位:1. 甘肃农业大学动物医学院,兰州,730060;甘肃畜牧工程职业技术学院,甘肃武威,733006
2. 中国农业科学院兰州畜牧与兽药研究所/新兽药重点开放实验室,兰州,730050
3. 甘肃农业大学动物医学院,兰州,730060
基金项目:国家高技术研究发展计划(863计划),中央级公益性科研院所基本科研业务费专项资金 
摘    要: 【目的】研究O/W型药用微乳形成的基本规律及评价方法,为药用微乳的研究和应用提供一定的实验依据。【方法】通过滴定法绘制拟三元相图,考察不同表面活性剂和助表面活性剂对O/W型微乳形成的影响。【结果】在相同油相的情况下,不同表面活性剂和助表面活性剂的不同结构和性质、表面活性剂和助表面活性剂的质量比(Km)、温度的变化对微乳的形成均有影响。【结论】恰当的油相和适配的表面活性剂和助表面活性剂的合理搭配,可以使微乳体系中表面活性剂的用量降低至7.5%,而且一般微乳形成的区域大小与表面活性剂和助表面活性剂的总量成正比,与油的用量成反比。用三元相图作为选择最佳微乳组方需要结合微乳的稳定性考察来确定微乳的最佳形成条件。

关 键 词:  微乳" target="_blank">face="Verdana">微乳  助表面活性剂  非离子型表面活性剂  拟三元相图
收稿时间:2008-04-28;

Preparation and Evaluation of O/W Pharmaceutical Microemulsions
LIU Gen-xin,ZHANG Ji-yu,WU Pei-xing,LI Jian-yong,LIU Ying,ZHOU Xu-zheng,WEI Xiao-juan,NIU Jian-rong,LI Bing.Preparation and Evaluation of O/W Pharmaceutical Microemulsions[J].Scientia Agricultura Sinica,2009,42(9):3328-3333.
Authors:LIU Gen-xin  ZHANG Ji-yu  WU Pei-xing  LI Jian-yong  LIU Ying  ZHOU Xu-zheng  WEI Xiao-juan  NIU Jian-rong  LI Bing
Institution:(College of Veterinary Medicine, Gansu Agricultural University)
Abstract:【Objective】 The basic formation rules and evaluation of the pharmaceutical microemulsions were studied in order to provide some experimental information to studying and application of pharmaceutical microemulsions. 【Method】 The titrimetric method for drawing pseudo-ternary phase diagrams was used to inspect the formation influence caused by different surfactants and CO-surfactant on the O/W microemulsions. 【Result】 In the same oil phase situation, the formation of microemulsions would be influenced by the structure and nature of surfactant and CO-surfactant, the quality ratio (Km) of surfactant and CO-surfactan as well as the temperature. 【Conclusion】 Appropriate oil phase and suitable matches of the surfactant and CO-surfactant can reduce the amount of surfactant in the microemulsion system to 7.5%. Moreover, in general, the region size of the microemulsions has a positive relationship with the total amount of surfactant and CO-surfactant, and has a negtive relationship with the oil used. In order to use drawing pseudo-ternary phase diagrams to determine the most excellent formation condition of pharmaceutical microemulsions, the stability of microemulsions needs to be unified.
Keywords:pharmaceutical microemulsions  CO-surfactant  non-ionic surfactant  pseudo-ternary phase diagram
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