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MnCl_2滴鼻后大鼠嗅球中锰、钙分布的关联性研究
引用本文:邹珍友,王金龙,智昊,成林,邹如意,周连伟,黄艳,成丹,胡海.MnCl_2滴鼻后大鼠嗅球中锰、钙分布的关联性研究[J].扬州大学学报(农业与生命科学版),2008,29(1):6-10.
作者姓名:邹珍友  王金龙  智昊  成林  邹如意  周连伟  黄艳  成丹  胡海
作者单位:1. 南京农业大学,生命科学实验中心-Perkin Elmer LLC.-Zeiss远东有限公司合作示范实验室,江苏,南京,210095
2. 上饶师范学院,化学系,江西,上饶,334001
3. 河北大学,工商学院,河北,保定,071002
基金项目:江苏省自然科学基金 , 南京农业大学生命科学实验中心开放课题基金
摘    要:采用MnCl2滴注大鼠鼻腔,分析嗅球截面上锰、钙等分布及其关联性,探讨锰示踪激活钙的神经通路机理.结果表明: 嗅球中锰、钙分别比滴鼻前增加54%和85%,呈现出外周各层高,中间嗅室、室管膜内低的盆地状关联分布.钙的增长区域比锰更深,达颗粒细胞层.嗅球腹外侧的锰及腹侧、外旁侧各层的钙增长显著;内侧各层的锰、钙虽多但变化小,各区神经密度差异影响Mn2 、Ca2 的传入与分布,说明Mn2 跨神经元传递时会损失.特定区域缺乏结合Mn2 的投射神经导致Mn2 、Ca2 含量低、变化小.Mn2 通过Ca2 通道和微管运输进入嗅神经细胞后抑制Ca2 外流,并跨突触传递到嗅球外周各层神经是Mn2 、Ca2 关联和增加的部分机制.

关 键 词:嗅球      Ca2  通道  微管运输
文章编号:1671-4652(2008)01-0006-05
修稿时间:2007年10月19

Studies on the correlation of Mn and Ca in certain sections of olfactory bulbs of rats after pipetting MnCl_2 solution
ZOU Zhen-you,WANG Jin-long,ZHI Hao,CHENG Lin,ZOU Ru-yi,ZHOU Lian-wei,HUANG Yan,CHNEG Dan,HU Hai.Studies on the correlation of Mn and Ca in certain sections of olfactory bulbs of rats after pipetting MnCl_2 solution[J].Journal of Yangzhou University:Agricultural and Life Science Edition,2008,29(1):6-10.
Authors:ZOU Zhen-you  WANG Jin-long  ZHI Hao  CHENG Lin  ZOU Ru-yi  ZHOU Lian-wei  HUANG Yan  CHNEG Dan  HU Hai
Institution:1.Cooper Lab of Lif Sci Exp Cen-Perkin Elmer LLC-Far East Branch of Zeiss Corp;Nanjing Agric Univ;Nanjing 210095;China;2.Dept of Chem;Shangrao Normal Coll;Shangrao 334001;3.Coll of Business;Hebei Univ;Baoding 071002;China
Abstract:A study was conducted to examine the Mn and Ca correlation in olfactory bulb(OB)and stimulation of Ca by Mn in neurons of rats.The contents of Mn and Ca were measured in certain sections of OB after MnCl2 solution piptted into nasal cavities.The results indicated that both Mn and Ca increased significantly,by 54% and 85% respectively,with their distributions being higher in periphery and lower in center.Ca distribution area was wider than that of Mn.Mn in external side and the Ca in ventral side enhanced re...
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