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Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography |
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| Authors: | H L Carrell J P Glusker J J Villafranca A S Mildvan R J Dummel E Kun |
| Abstract: | The fluorocitrate isomer that is a strong inhibitor and inactivator of aconitase has been shown by x-ray crystallographic studies on the rubidium ammonium salt to have the configurations (1R : 2R) or (1S : 2S) 1-fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid. A possible mechanism for the action of fluorocitrate is proposed which involves the 1R : 2R isomer suggested from biochemical data. |
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