天然产物(E)-白黎芦醇的全合成

摘要为探讨原料易得、操作简单的天然产物白黎卢醇合成方法，以3，5-二羟基苯甲酸为原料，通过甲基化、还原、溴化、Arbuzov重排，生成关键中间体3，5-二甲氧基苄基膦酸酯，再与对甲氧基苯甲醛经Wittig-Horner缩合，用三溴化硼脱甲基，得到单一的反式白黎芦醇，产率为39．3％。结果表明，本方法原料廉价易得，各步反应产物无需柱色谱分离，因而操作简单，易于扩大生产。

Synthesis of natural resveratrol

The synthetic method of resveratrol was investigated in this study, in which with the raw materials should be readily available and cheap, and with simple manipulation. 3,5-dihydroxy benzoic acid was used as the starting substance. The key intermediate of 3,5-dimethoxy-benzyl-phosphonate was obtained through four steps of methylation, reduction, bromination, and arbuzov rearrangment. Following polymerization with anisaldehyde by Wittig-Horner reaction and demethylation with boron tribromidethe final product of resveratrol was obtained.The overall yield was 39.3%. In conclusions, this process had some advantages of commercially available,cheap starting materials, no requirement of chromatography and convenient manipulation.