左卡尼汀对高脂血症大鼠血脂代谢的影响及抗氧化作用

为了观察左卡尼汀( L-carnitine,LC)对高脂血症大鼠血脂代谢的影响及抗氧化作用,将50只健康SD大鼠随机分成5组,分别接受标准饲料、高脂饲料、高脂饲料加低、中、高剂量(0.25、0.50、1.00g/(kg·d)]LC灌胃处理.连续灌服给药28 d后,测定大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量及血清和肝脏中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量.结果表明,与高脂模型组相比,给予LC可显著降低血清TC、TG、LDL-C含量,增加HDL-C含量;血清和肝脏中SOD活性提高、MDA含量降低(P＜0.05).表明LC对高脂血症大鼠有明显的降血脂和改善体内抗氧化能力的作用.

Effects of L-carnitine on Blood Lipid Metabolism and Antioxidation in Hyperlipidemia Rats

50 healthy SD rats were randomly divided into 5 groups and fed with control diet,high-cholesterol diet and high-cholesterol diet adding L-carniline(LC)at different dose0.25,0.50 and 1.00 g/(kg·d)] by orally administration to study the effects of LC on the blood lipid metabolism in hyperlipidemia rats and its antioxidation.The content of total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C) and low density lipoprotein(LDL-C) in serum,the activity of superoxide dismutase(SOD) and the content of malondiadehyde(MDA) in serum and liver of each group were detected after 28 days.The results showed that compared with hyperlipid model group,the content of TC,TG and LDL-C in the serum of LC treated group was significantly decreased;the HDL-C level was increased;the SOD activities in serum and liver were higher and the MDA contents were decreased(P<0.05).It was indicated that LC might play an important role in lowering the high blood lipid and improving the vivo antioxidant capacity in hyperlipidemia rats.