| 病毒基因沉默抑制因子与AGO蛋白结合抑制RNA沉默的研究进展 |
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| 引用本文： | 申永梅,杨纪君,霍晓辉,田东方,曹雪松.病毒基因沉默抑制因子与AGO蛋白结合抑制RNA沉默的研究进展[J].天津农业科学,2012,18(1):23-27. |
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| 作者姓名： | 申永梅 杨纪君 霍晓辉 田东方 曹雪松 |
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| 作者单位： | 1. 聊城大学生命科学学院,山东聊城,252059
2. 山东省委党校,山东济南,250103 |
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| 基金项目： | 国家自然科学基金(30870109) |
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| 摘 要： | 总结了RNA沉默及病毒RNA沉默抑制因子(VSRs)的研究进展,以及病毒基因沉默抑制因子利用甘氨酸/色氨酸(GW)模型作为ARGONAUTE(AGO)钩和寄主发生RNA沉默的重要作用部位相互结合从而抑制基因沉默的研究机制。通过研究发现,在酵母、动植物细胞中,一些包含GW模型的蛋白质被认为是RNA沉默效应复合物中AGOs的重要协助者。结果说明,GW模型是一种能用于调节RNA沉默途径活性的万能的、有效的工具,用GW模型竞争性结合AGOs并抑制寄主基因沉默可能是一种被许多病原菌用于抵抗寄主RNA沉默的方法。
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| 关 键 词： | RNA沉默 VSRs AGO蛋白 GW模型 |
Evolution of Restraining Host RNA Silencing by Binding of Viral Suppressor Protein and Argonautes |
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| SHEN Yong-mei
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YANG Ji-jun
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HUO Xiao-hui
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TIAN Dong-fang
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CAO Xue-song.Evolution of Restraining Host RNA Silencing by Binding of Viral Suppressor Protein and Argonautes[J].Tianjin Agricultural Sciences,2012,18(1):23-27. |
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| Authors: | SHEN Yong-mei YANG Ji-jun HUO Xiao-hui TIAN Dong-fang CAO Xue-song |
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| Institution: | 1(1.College of Life Science,Liaocheng University,Liaocheng,Shandong 252059,China;2.Shandong Provincial Committee School,Jinan,Shandong 250103,China) |
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| Abstract: | This paper summed up the evolution of RNA silence and viral suppressors of RNA silencing(VSRs),and viral suppressors of RNA silencing use glycine/tryptophane(GW) motifs as an ARGONAUTE(AGO) hook inhibit gene silence by binding the important location of RNA silence.Through the study we found that,in yeast,animal and plant cells,some protein containing GW motifs was considered to be important partners of AGOs in RNA silencing effector complexes.The result indicated the GW motif seemed to be a universal and effective tool for regulating the activities of RNA silencing way,and many pathogens may use the method of GW motif competing for and restraining host AGOs to counteract host RNAi-based defenses. |
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| Keywords: | RNA silencing VSRs argonaute protein GW motifes |
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