| 慢性持续期支气管哮喘患者痰液中IL-4水平与其临床基线评估相关性分析 |
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| 引用本文： | 许菊秀,黄晓霞,马家兰,肖卫,陈振平,胡伟华.慢性持续期支气管哮喘患者痰液中IL-4水平与其临床基线评估相关性分析[J].长江大学学报,2009(2). |
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| 作者姓名： | 许菊秀 黄晓霞 马家兰 肖卫 陈振平 胡伟华 |
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| 作者单位： | 长江大学附属第一医院荆州市第一人民医院呼吸内科; |
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| 摘 要： | 目的:探讨慢性持续期支气管哮喘患者痰液中白细胞介素-4(IL-4)水平与其临床基线评估的相关性。方法:分别对慢性持续期支气管哮喘患者轻度16例、中度14例、重度18例进行临床基线评估,主要是肺功能检测及哮喘症状控制评分;并同时采用酶联免疫吸附试验(ELISA)法检测其诱导痰液中IL-4水平。结果:慢性持续期支气管哮喘患者痰液中IL-4水平与肺通气功能指标FEV1%呈负相关,与哮喘发作程度临床症状评分相一致。结论:慢性持续期支气管哮喘患者痰液中IL-4水平与其发作程度有关,能作为哮喘评估的一项指标。
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| 关 键 词： | 支气管哮喘 白细胞介素-4 肺功能 |
Correlation between the IL-4 Level of Sputum and Asthma Symptom Score and Lung Function at Baseline in Patients with Bronchial Asthma on Chronic Duration Stage |
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| XU Ju-xiu,HUANG Xiao-xia,MA Jia-lan,XIAO Wei,CHENG Zheng-ping,HU Wei-hua.Correlation between the IL-4 Level of Sputum and Asthma Symptom Score and Lung Function at Baseline in Patients with Bronchial Asthma on Chronic Duration Stage[J].Journal of Yangtze University,2009(2). |
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| Authors: | XU Ju-xiu HUANG Xiao-xia MA Jia-lan XIAO Wei CHENG Zheng-ping HU Wei-hua |
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| Institution: | Department of Respiration;the First Hospital of Yangtze University;Jingzhou 434000;China |
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| Abstract: | Objective:To investigate the correlation between the IL-4 level of sputum and asthma symptom score and lung function At baseline in patients with bronchial asthma on chronic duration stage. Methods:16 mild,14 moderate and 18 severe patients with bronchial asthma on chronic duration stage,as well as 15 normal control subjects, were included in this study. At baseline, asthma symptom score was recorded, and lung function was measured. Induced sputum was obtained and the IL-4 level of sputum was determined wit... |
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| Keywords: | Bronchial asthma Interleukin-4 Lung function |
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