慢性充血性心力衰竭患者血清心肌肌钙蛋白I和C-反应蛋白的变化

目的:探讨慢性充血性心力衰竭(CHF)患者心功能改善前后血清心肌肌钙蛋白I(cTnI)及C-反应蛋白(CRP)的变化及意义。方法:37例慢性充血性心力衰竭(NYHA分级Ⅲ~Ⅳ级)患者分别于入院d2和心功能改善至Ⅰ~Ⅱ级后抽取血清作cTnI、CRP测定。结果:治疗前患者血清cTnI阳性率54.1%,CRP超正常范围占78.4%。经治疗心功能改善后患者血清cTnI阳性率21.6%(P<0.01),CRP超正常范围占35.1%(P<0.01)。结论:部分慢性充血性心力衰竭患者心功能恶化时存在心肌损伤或坏死,此过程随心功能改善而改变,部分可能与其它因素有关。

Change in Serum Troponin I(cTnI) and C-reactive protein(CRP) in Patients with Congestive Heart Failure(CHF)

Objective: To study the changes of serum cardiac Troponin I(cTnI) and C-reactive protein(CRP) in patients with congestive heart failure(CHF) before and after improvement of their cardiac function.Methods: 37 patients with congestive heart failure(NYHA class III ~ IV) were recruited.Blood tests for cTnI and CRP were performed on the second day of admission as well as when their cardiac function was improved to NYHA class I~II.Results: Before treatment,the cTnI tests were positive in 20 patients(54.1%) and the CRP level exceeded normal level in 29 patients(78.4%).After treatment with improved cardiac function,the cTnI tests were positive in 8 patients(21.6%,P<0.01) and the CRP level exceeding normal level in 13 patients(35.1%,P<0.01).Conclusion: Part of the patients with congestive heart failure have myocardial injury or infarction when they have deterioration of their cardiac function.This process will change as the cardiac function improved.Part of patients may have other factors for the deterioration of cardiac function.