| UBL5基因的结构与功能研究 |
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| 引用本文： | 商书交,周燕,娄兴亮,高述民,范春霞.UBL5基因的结构与功能研究[J].北京林业大学学报,2010,32(5):172-176. |
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| 作者姓名： | 商书交 周燕 娄兴亮 高述民 范春霞 |
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| 作者单位： | 1北京林业大学林木育种国家工程实验室，林木花卉遗传育种教育部重点实验室，国家林业局树木花卉育种与生物工程重点开放实验室，北京林业大学生物科学与技术学院 2 北京市园林科学研究所 |
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| 基金项目： | 国家自然科学基金，北京林业大学"211工程"三期研究生创新人才培养建设计划子项目 |
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| 摘 要： | 几乎每个真核生物都有UBL5的同源基因。UBL5蛋白在单泛素化H2B、mRNA前体剪接、细胞周期调控、能量代谢以及抗压等方面起着重要的作用。UBL5是近几年发现的一种新类型的类泛素蛋白(UBL),它与泛素及类泛素的三维结构相似,只是C末端的双酪氨酸取代了保守的双甘氨酸。在参考了相关文献资料的基础上,结合本实验室在文冠果UBL5基因克隆及功能鉴定方面所做的初步研究工作,对UBL5基因的克隆、蛋白结构、功能等方面进行了综述。
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| 关 键 词： | UBL5 H2B泛素化 mRNA前体剪接 细胞周期 |
| 收稿时间： | 1900-01-01 |
Research on UBL5 gene and its product structure and function |
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| SHANG Shu-jiao,ZHOU Yan,LOU Xing-liang,GAO Shu-min,FAN Chun-xia.Research on UBL5 gene and its product structure and function[J].Journal of Beijing Forestry University,2010,32(5):172-176. |
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| Authors: | SHANG Shu-jiao ZHOU Yan LOU Xing-liang GAO Shu-min FAN Chun-xia |
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| Institution: | 1 National Engineering Laboratory for Tree Breeding, Key Laboratory of Genetics and Breeding in Forest and Ornamental Plants of Ministry of Education, Tree and Ornamental Plant Breeding and Biotechnology Laboratory of State Forestry Admination,College of Biological Sciences and Biotechnology, Beijing Forestry University, 100083, P.R. China; 2 Beijing Institute of Landscape Gardening, 100102, P.R. China. |
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| Abstract: | Orthologs of UBL5 almost occur in every eukaryotic genome. UBL5 plays an important role in H2B monoubiquitination, pre-mRNA splicing, cell cycle regulation, energy metabolism, stress,etc. UBL5 is a novel class of the UBL protein family.The tertiary structure of UBL5 is similar to that of ubiquition and ubiquition-like proteins;however, UBL5 contains a C-terminal di-tyrosine motif instead of the conserved di-glycine. All those are based on plenty of references and the research about cloning UBL5 from Xanthoceras sorbifolia Bunge. in our laboratory. This paper reviews the latest results about UBL5 gene in the aspects of its cloning, structure and function. |
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| Keywords: | UBL5 H2B monoubiquitination pre-mRNA splicing cell cycle |
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