| 三种长效磺胺药在水牛体内的代谢动力学 |
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| 引用本文： | 张福华,夏珍,柳仲华,张心如,周祖华,付佑全.三种长效磺胺药在水牛体内的代谢动力学[J].四川农业大学学报,1984(2). |
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| 作者姓名： | 张福华 夏珍 柳仲华 张心如 周祖华 付佑全 |
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| 作者单位： | 四川农学院，四川农学院，四川农学院，四川省新津县农科所，四川农学院，四川农学院 |
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| 摘 要： | <正> 磺胺—5,6—二甲氧嘧啶(SDM')为人用的周效磺胺。在奶山羊体内的代谢动力学已进行了研究。磺胺—5—甲氧嘧啶(SMD)和磺胺—6—甲氧嘧啶(SMM、DS—36)亦为人用长效磺胺。SMM在鸡体内的分布、在牛、猪的血中浓度、血浆蛋白结合率如乙酰化率、对马和奶山羊体内的代谢动力学已进行了研究。
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| 关 键 词： | PHARMACOKINETICS (47UA) BUFFALO (49ME) DRUG PLASMA CONCENTRATION LONG—ACTING SULFONAMIDES |
PHARMACOKINETICS OF SULFADOXINE (SDM), SULFAMETHOXYDIAZINE (SMD), AND SULFAMONOMETHOXINE (SMM) IN BUFFALOES |
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| Zhang Fuhua Xia Zhen Liu Zhonghua Zhang Xinru Zhou Zuhua Fu youguan.PHARMACOKINETICS OF SULFADOXINE (SDM), SULFAMETHOXYDIAZINE (SMD), AND SULFAMONOMETHOXINE (SMM) IN BUFFALOES[J].Journal of Sichuan Agricultural University,1984(2). |
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| Authors: | Zhang Fuhua Xia Zhen Liu Zhonghua Zhang Xinru Zhou Zuhua Fu youguan |
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| Abstract: | Pharmacokinetics of sulfadoxine, sulfamethoxydiazine, and sulfamonomethoxone for injections were studied in healthy adult buffaloes. A single dose(SDM′70mg/kg, SMD 50mg/kg, SMM 70mg/kg and 100mg/kg) of drugs administered as an intravenous bolus,and blood samples were collected at precisely timed intervals. The samples were analyzed chemically (spectrophotometric assay)by the Annino method (SDM′and SMD) and the Eckert method (SMM). The pharacokintic models were in accordance with those specified. The main kinetic parameters of SDM′, SMD, and SMM (Ⅳ70mg/kg and Ⅳ 100mg/kg) were determined. |
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| Keywords: | PHARMACOKINETICS (47UA) BUFFALO (49ME) DRUG PLASMA CONCENTRATION LONG—ACTING SULFONAMIDES |
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