环丙沙星在山羊体内药代动力学研究

本文报道以高压液相色谱法为定量手段，研究了六头本地山羊一次肌肉注射环丙沙星（2.8mg／kg）后，血中环丙沙星的药代动力学规律。测定条件：shimpackCLC-ODS,150×6mm不锈钢柱；流动相：甲醇-乙腈-0.02mol／L磷酸二氢钾溶液（10：10：80V／V／V；内含0.3％四丁基氢氧化铵，pH2.8±0.2）；紫外检测波长：277nm。吡哌酸作内标，主要药动学参数为：M＝3.59±1.83（μg／mL）；Ka＝（4.01±1.13）／h；K=（0.55±0.31）／h;T(1/2)Ka=0.18±0.06（h）；T(1/2)K＝1.69±1.06（h）；Tmax＝0.61±0.16（h）；Cmax=2.09±0.7（μg／mL）；AUC＝58.3±1.34［μg／（mL.h）］；CL(B)=0.51±0.21［mL／（kg.h）］；V＝1.10±0.45（L／kg）。

PHARMACOKINETICS STUDIES OF CIPROFLOXACIN IN GOATS

This paper reports a method for determination of Ciprofloxacin in serum healthy goats aftrr a singl intramuscular dose at rater of 2. 8 mg/kg body weigth by HPLC.It was chosen shim-pack-CLC ods as asolid phase and the mobil phase consisted of methanolacetonituile -0.02mol /L potassium dihydrogenphosphate (10:10. 80 V/V/V pH= 2. 8 ±0. 2) at a flow at 1.0 mL min, The wavelength of uv detector was 227 nm. Pipemidic acid was used and internal. The major parameters are: M=3. 59 ±1. 83 μg/mL; Ka= (4. 01±1. 13) /h; K = (0. 55±0.31) /h；T (1/2) Ka= 0. 18 ±0.06h；T (1/2) K=1.69 ±1. 06h；Tmiax=0. 61±0. 16h; Cmax=2. 09±0. 7 μg/mL; AUC = 5. 83 ±1. 34 μg/(mL. h); CL (B) =0. 51±0. 12mL/ (kg. h); V=1. 10 ±0. 45L/kg.