| C_(60)-D-氨基葡萄糖衍生物的制备及其抗氧化性的研究 |
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| 引用本文： | 孙涛,巢骏,熊小英,康永锋,谢晶.C_(60)-D-氨基葡萄糖衍生物的制备及其抗氧化性的研究[J].上海海洋大学学报,2010(3). |
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| 作者姓名： | 孙涛 巢骏 熊小英 康永锋 谢晶 |
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| 作者单位： | 上海海洋大学食品学院; |
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| 基金项目： | 上海海洋大学骆肇荛大学生科技创新基金项目(G-7101-00-000727); 上海市生物医药和农业科技领域重点科技项目(08391911500); 2009年上海市优秀学科带头人计划(09XD1402000); 上海市教委重点学科(J50704) |
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| 摘 要： | 在非均相碱性体系中,合成了C60-D-氨基葡萄糖衍生物,用FT-IR和1HNMR对产物的结构进行了表征。考察了C60-D-氨基葡萄糖衍生物的超氧阴离子清除能力、羟基自由基清除能力、还原能力以及金属螯合能力。结果表明:C60-氨基葡萄糖衍生物对超氧阴离子自由基O2-.和羟基自由基.OH的半抑制浓度分别是0.42mg/mL和0.26mg/mL;在还原能力体系中当吸光度达到0.5时,所需C60-D-氨基葡萄糖衍生物的浓度是2.44mg/mL;在金属螯合能力体系中,C60-D-氨基葡萄糖衍生物对亚铁离子的半螯合浓度是0.013mg/mL;即表明C60-D-氨基葡萄糖衍生物在4个抗氧化体系中都表现出明显的抗氧化性。并且D-氨基葡萄糖盐酸盐在4个体系中表现出的抗氧化能力都不强,说明C60-D-氨基葡萄糖衍生物的抗氧化能力可能主要来自于C60上保留下来的双键。
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| 关 键 词： | C60-D-氨基葡萄糖衍生物 超氧阴离子 羟基自由基 还原能力 金属螯合能力 |
Research on synthesis of D-Glucosamine C_(60) derivative and its antioxidant activities |
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| SUN Tao,CHAO Jun,XIONG Xiao-ying,KANG Yong-feng,XIE Jing.Research on synthesis of D-Glucosamine C_(60) derivative and its antioxidant activities[J].Journal of Shanghai Ocean University,2010(3). |
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| Authors: | SUN Tao CHAO Jun XIONG Xiao-ying KANG Yong-feng XIE Jing |
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| Abstract: | In heterogeneous phase alkaline system,D-glucosamine C60 derivative was synthesized.The product was characterized by FT-IR and 1H NMR.The antioxidant activities of D-glucosamine C60 derivative,including scavenging ability on superoxide anion and hydroxyl radical,reducing power and chelating ability were studied.The results showed that 50% inhibiting concentrations of D-glucosamine C60 derivative for superoxide anion and hydroxyl radical were 0.42 mg/mL and 0.26 mg/mL,respectively,the effective concentration... |
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| Keywords: | D-glucosamine C60 derivative superoxide anion hydroxyl radical reducing power chelating ability |
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