| DNA甲基化作用的生物学功能 |
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| 引用本文： | 郑小梅,伍宁丰.DNA甲基化作用的生物学功能[J].中国农业科技导报,2009,11(1):33-39. |
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| 作者姓名： | 郑小梅 伍宁丰 |
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| 作者单位： | 中国农业科学院生物技术研究所, 北京 100081 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | DNA甲基化作为DNA序列的修饰方式,是一种重要的表观遗传机制,能够在不改变DNA分子一级结构的情况下调节基因组的功能,在生命活动中起着重要的作用。其功能主要可归结为以下4个方面：维持基因组遗传物质的稳定性,调控基因的表达,建立表观遗传模式以及参与细胞及胚胎的形态建成。
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| 关 键 词： | DNA甲基化 DNA甲基转移酶 表观遗传 印迹基因 X-染色体失活 |
| 收稿时间： | 2008-10-09 |
| 修稿时间： | 2008-12-22 |
Biological Function of DNA Methylation |
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| ZHENG Xiao-mei,WU Ning-feng.Biological Function of DNA Methylation[J].Journal of Agricultural Science and Technology,2009,11(1):33-39. |
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| Authors: | ZHENG Xiao-mei WU Ning-feng |
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| Institution: | Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China |
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| Abstract: | DNA methylation, as one kind of modification way of DNA sequences, is an important epigenetic mechanism. It can regulate the expression of many vital genes while the base compositions of these genes do not change, therefore DNA methylation is very important to the growth and development of organism. In this paper, we summarized the rules of DNA methylation into four aspects, as follows: maintaining the stability of genetic information in genomes; regulating the expression of genes; establishing epigenetic patterns and participating in the development of embryos. |
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| Keywords: | DNA methylation DNA methyltransferases epigenetics imprinting genes X chromosome inactivation |
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