| 环丙沙星与粘菌素联合对猪大肠杆菌的体外抗菌研究 |
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| 引用本文： | 晁利刚,谷晓霞,胡功政,莫娟,潘玉善.环丙沙星与粘菌素联合对猪大肠杆菌的体外抗菌研究[J].江西农业学报,2009,21(1). |
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| 作者姓名： | 晁利刚 谷晓霞 胡功政 莫娟 潘玉善 |
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| 作者单位： | 河南农业大学,牧医工程学院,药理实验室,河南,郑州,450002 |
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| 摘 要： | 测定了环丙沙星与粘菌素对分离的猪大肠杆菌的最小抑菌浓度(MIC)及两药联用对猪大肠杆菌的部分抑菌浓度(FIC)指数。实验结果表明:环丙沙星对5株大肠杆菌的MIC≥32μg/mL,粘菌素的MIC≥16μg/mL;环丙沙星与粘菌素联用时,FIC指数介于0.09375~0.125,并可同时显著降低两药的MIC值,表现为显著的协同作用。
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| 关 键 词： | 环丙沙星 粘菌素 最小抑菌浓度(MIC) 部分抑菌浓度(FIC)指数 联合用药 |
Antibacterial Activity of Combination of Ciprofloxacin and Colistin against Isolated E. coli from Pigs |
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| CHAO Li-gang,GU Xiao-xia,HU Gong-zheng,MO Juan,PAN Yu-shan.Antibacterial Activity of Combination of Ciprofloxacin and Colistin against Isolated E. coli from Pigs[J].Acta Agriculturae Jiangxi,2009,21(1). |
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| Authors: | CHAO Li-gang GU Xiao-xia HU Gong-zheng MO Juan PAN Yu-shan |
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| Institution: | Laboratory of Pharmacology;College of Animal Husbandry and Veterinary Engineering;Henan Agricultural University;Zhengzhou 450002;China |
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| Abstract: | The minimum inhibitory concentration(MIC) value of Ciprofloxacin and Colistin against E.coli isolated from pigs was determined by using liquid double micro-dilution method,and the fractional inhibitory concentration(FIC) index of the combination of above two drugs was determined by using micro-board method,which could provide a theoretical basis for the development of new compound formulations of Ciprofloxacin.The results showed that: the MIC value of Ciprofloxacin against E.coli was ≥ 32 μg/mL,the MIC value of Colistin against E.coli was ≥ 16 μg/mL;when Ciprofloxacin and Colistin were combined,the MIC value was ≤ 8 μg/mL and ≤ 4 μg/mL respectively;the FIC index of their combination ranged from 0.09375 to 0.125.When Ciprofloxacin and Colistin were combined,the MIC value of them could be reduced,which showed significant synergies. |
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| Keywords: | Ciprofloxacin Colistin Minimum inhibitory concentration(MIC) Fractional inhibitory concentration(FIC) index Combination |
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