| Gsα的过表达和缺失对果蝇大脑形态发育的影响 |
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| 引用本文： | 姜文超.Gsα的过表达和缺失对果蝇大脑形态发育的影响[J].东北农业大学学报,2010,41(4). |
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| 作者姓名： | 姜文超 |
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| 作者单位： | 清华大学生命科学学院,北京,100084 |
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| 基金项目： | 清华大学罗弘实验室科研启动基金 |
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| 摘 要： | Gsα作为G蛋白复合体的重要组成部分,通过直接调控cAMP-PKA等信号通路参与调控细胞的生命活动。文章通过构建Gsα过量表达及失活突变体,研究Gsα的过量表达及失活对果蝇神经细胞发育的影响。结果表明,在25℃培养条件下,Gsα的过量表达对果蝇幼虫具有致死性。但Gsα的过量表达及失活对果蝇神经细胞的细胞周期和细胞极性没有显著影响。
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| 关 键 词： | 果蝇大脑 Gsα 过量表达 失活 |
Impact on Drosophila brain development through overexpression and loss of GSG function |
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| JIANG Wenchao.Impact on Drosophila brain development through overexpression and loss of GSG function[J].Journal of Northeast Agricultural University,2010,41(4). |
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| Authors: | JIANG Wenchao |
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| Abstract: | As an important component of G protein complex,Gsα mediated many cell activities through directly activating the cAMP-PKA pathway.The impact on the development of Drosophila brain was studied by the method of overexpression and loss of Gsα function.The results showed that the overexpression of Gsα caused the larvae to die at 25℃.But the overexpression of Gsα and loss of Gsα function had no evident impacts both on the cell cycle and cell polarity of Drosophila nerve cells. |
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| Keywords: | Drosophila brain overexpression loss of function |
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