| 喹乙醇对鸡骨髓细胞染色体畸变和微核率的影响 |
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| 引用本文： | 由天姿,贾琳琳,贺笛,李术.喹乙醇对鸡骨髓细胞染色体畸变和微核率的影响[J].东北农业大学学报,2010,41(7). |
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| 作者姓名： | 由天姿 贾琳琳 贺笛 李术 |
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| 作者单位： | 东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030 |
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| 基金项目： | 环保公益性科研专项经费资助项目 |
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| 摘 要： | 为了评价喹乙醇对家禽的致突变性,试验将鸡分为试验组(150 mg.kg-1.diet喹乙醇)、阴性对照组(灭菌生理盐水)、阳性对照组(环磷酰胺),连续染毒15 d,间隔5 d采样一次,检测骨髓细胞染色体畸变率和微核率。结果表明,试验组骨髓细胞染色体畸变率和微核率与阴性对照组比较差异显著(P0.01),且呈时间-效应关系。表明喹乙醇是鸡骨髓细胞突变的诱变剂。
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| 关 键 词： | 喹乙醇 鸡 骨髓细胞 染色体畸变 微核率 |
Effect of Olaquindox on chromosome aberration and micronuclear rate for bone marrow cells of chicks |
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| YOU Tianzi,JIA Linlin,HE Di,LI Shu.Effect of Olaquindox on chromosome aberration and micronuclear rate for bone marrow cells of chicks[J].Journal of Northeast Agricultural University,2010,41(7). |
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| Authors: | YOU Tianzi JIA Linlin HE Di LI Shu |
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| Abstract: | The purpose was to determine the mutagenicity of experimental Olaquindox poisoning in poultry.Chicks were divided into experimental group(150 mg.kg-1.diet Olaquindox),negative control group(sterile saline) and positive control group(cyclophosphamide).Three groups of chicken were administered the abovementioned agentia by lavage for 15 days,every five days to do a test.And then chromo-some aberrated rates of bone marrow cells and the micronucleum rates were detected.The results showed that chromosome aberration test and microcleus test in chicks were positive and showed the time-effect relationship.It was concluded that Olaquindox poisoning could induce the injury of bone marrow cells of chicks. |
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| Keywords: | Olaquindox chick bone marrow cell chromosome aberration micronuclear rate |
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