氨苄青霉素在马体内的代谢动力学

本文报告了氨苄青霉素在健康成年马体内的代谢动力学过程。选用了合适的动力学模型描述了氨苄青霉素的药动学特点。计算出氨苄青霉素的药动学参数如下:消除半衰期(t(1/2)β),2.23±0.37(小时),吸收半衰期(t(1/2)Kα),0.15±0.09(小时),峰时(tp),0.46±0.23(小时),峰浓度(Cmax),8.19±1.13(μg/ml),有效血浆浓度维持时间Tcp(ther),4.54±1.46(小时)。还根据单剂量给药的参数值,推算出多剂量给药的参数。

PHARMACOKINETICS OF AMPICILLIN IN THE HORSES

This investigation reported pharmacokinetic process of Ampicillin in healthy adult horses. The pharmacokinetic characteristics of drug were described by suitable kinetic model. The pharmacokinetic parameters calculated were as follows: Elimination half-life(t(1/2)β) was 2.23±0.37(h) . Absorption half-time (t(1/2)ka)was 0.15 ± 0.09(h). Time of peak concentration(tp) was 0.46 ± 0.23 (h). The maximum, average and minimum plateau plasma concentration were 8. 89 ± 1.07(μg/ml), 2.17 ± 1. 34 (μg/ ml) and 4.75±1.27 (μg/ml), respectively. Duration of therapeutic plasma level of a drug Tcp (ther)] was 4.54 ±1.46 (h) . The parameters of multiple dosing were estimated.