| 苯甲酸钠对小鼠骨髓细胞的致突变作用研究 |
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| 引用本文： | 吕娜,沈明浩.苯甲酸钠对小鼠骨髓细胞的致突变作用研究[J].吉林农业大学学报,2006,28(4):466-468. |
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| 作者姓名： | 吕娜 沈明浩 |
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| 作者单位： | 吉林农业大学食品工程学院,长春,130118 |
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| 摘 要： | 采用小鼠骨髓细胞微核试验、小鼠骨髓细胞染色体畸变试验研究了食品防腐剂苯甲酸钠对小鼠骨髓细胞的致突变作用。结果显示:小鼠骨髓细胞微核试验及小鼠骨髓细胞染色体畸变试验均呈阳性(P<0.01),证明苯甲酸钠是染色体断裂剂,而且对雄性动物的致突变作用更大,所引起的染色体结构畸变以染色体断裂为主要类型。
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| 关 键 词： | 苯甲酸钠 小鼠 突变 微核 染色体 |
| 文章编号： | 1000-5684（2006）04-0466-03 |
| 收稿时间： | 2005-10-30 |
| 修稿时间： | 2005-10-302006-04-15 |
Research on Mutagenicity of Sodium Benzoate in Born Marrow Cells |
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| L Na,SHEN Ming-hao.Research on Mutagenicity of Sodium Benzoate in Born Marrow Cells[J].Journal of Jilin Agricultural University,2006,28(4):466-468. |
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| Authors: | L Na SHEN Ming-hao |
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| Institution: | College of Food Engineering, Jilin Agricultural University, Changchun 130118, China |
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| Abstract: | Microcleus test and chromosome aberration test were used to ascertain the mutagenicity of sodium benzoate in born marrow cells.The results showed that microcleus test and chromosome aberration test in mice were positive.So sodium benzoate is chromosome clastogen.And the mutagenesis to male is greater than that to female.Isochromatid break is the main type of chromosome aberration. |
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| Keywords: | sodium benzoate mice mutagenicity microcleus chromosome |
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