| 硝唑尼特的一般毒性和致突变性研究 |
| |
| 引用本文： | 张德利,吴永魁,张瑞岩,李乾学,张西臣.硝唑尼特的一般毒性和致突变性研究[J].吉林农业大学学报,2011,33(5):576-580. |
| |
| 作者姓名： | 张德利 吴永魁 张瑞岩 李乾学 张西臣 |
| |
| 作者单位： | 1. 军事医学科学院军事兽医研究所,吉林省人兽共患病预防与控制重点实验室,长春130122
2. 吉林大学畜牧兽医学院,长春,130062 |
| |
| 基金项目： | 国家“十一五”科技支撑计划项目(2006BAD31B04) |
| |
| 摘 要： | 通过小鼠经口急性毒性试验、蓄积毒性和耐受性试验研究了硝唑尼特的一般毒性；通过Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验研究了硝唑尼特的致突变性.结果表明:硝唑尼特对小鼠口服LD50为6.295 g/kg,属实际无毒类物质；对小鼠20d给药蓄积系数K＞5.26,属弱蓄积或基本无蓄积毒性,未产生耐受性；对组氨酸缺...
|
| 关 键 词： | 硝唑尼特 急性毒性 蓄积毒性 致突变性 |
General Toxicity and Mutagenicity of Nitazoxanide |
| |
| ZHANG De-li,WU Yong-kui,ZHANG Rui-yan,LI Qian-xue,ZHANG Xi-chen.General Toxicity and Mutagenicity of Nitazoxanide[J].Journal of Jilin Agricultural University,2011,33(5):576-580. |
| |
| Authors: | ZHANG De-li WU Yong-kui ZHANG Rui-yan LI Qian-xue ZHANG Xi-chen |
| |
| Institution: | ZHANG De-li1,WU Yong-kui1,ZHANG Rui-yan1,LI Qian-xue1,ZHANG Xi-chen21.Institute of Military Veterinary,AMMSA,Key Laboratory of Jilin Province for Zoonosis Prevention and Control,Changchun 130122,China,2.College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062 |
| |
| Abstract: | The general toxicity of nitazoxanide was investigated by acute toxicty test,accumulative toxicity and tolerance test of mice;the mutagenicity of nitazoxanide was evaluated by Ames test,marrow cell micronucleus test and sperm malformation test of mice.The results showed that mice acute oral LD50 of nitazoxanide was 6.295 g/kg,belonging to no toxic substance.The 20 d administration accumulation coefficient was K>5.26 which demonstrated that nitazoxanide was low or not accumulated.Through the Ames test,micronu... |
| |
| Keywords: | nitazoxanide acute toxicity accumulative toxicity mutagenicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
